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Title   진행위암환자의 종양침윤림프구와 종양주변 림프절 림프구의 면역학적 특성 ( The Immunological Caracteristics of Tumor Infiltrating Lymphocytes and Tumor Draining Lymph Node Lymphocytes in Advanced Stomach Cancer )
Publicationinfo   1992 Jan; 024(05): 656-666.
Key_word   Stomach cancer, Tumor-infiltrating lymphocytes, Natural Killer cell activity
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Abstract   It has been known that lymphocytes infiltrate in and around the malignant tumor. However, the characteristics and function of the tumor-infiltrating lymphocytes are not known clearly. It is not known whether the lymphocytes infiltrate the tumor without any purposes or they are in there with a specific purpose, such as to control the growth of the tumor. Same is true with the lymphocytes of tumor-draining lymph nodes. In order to answer the questions, the following experiments were done. Tumor masses, perigastric lymph nodes, and peripheral blood were taken from 34 patients with advanced gastric cancer. Single-cell suspensions of lymphocytes from those sepecimens were evaluated in terms of the cytotoxicity against K562 and Daudi cell lines, and surface phenotyping. The cytotoxicity of the lymph node lymphocytes and tumor-infiltrating lymphocytes was lower than that of peripheral blood lymphacytes. The portion expressing natural killer cell (CD16, CD56, CD57) of the lymph node lymphocytes and tumor-inffiltrating lymphocytes were also lower than that of peripheral blood lymphocytes. There was no difference between tumor-involved lymph nodes and non-involved lymph nodes in terms of the cytotoxicity and the surface marker of the lymphocytes.
저 자   이재용(Jae Yong Lee),허대석(Dae Seog Heo),장정순(Joung Soon Jang),박영이(Young Iee Park),최기영(Chee Young Choe),김우호(Woo Ho Kim),김철우(Chul Woo Kim),김용일(Yong Il Kim),김노경(Noe Kyeong Kim),장우현(Woo Hyun Chang)